Virion assembly

Across TCGA patient cohorts, RNA activity of the Virion assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM54, SMC4, and TEAD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Virion assembly activity versus TRIM54 in LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIM54 →	+0.539	+0.086	.001	.002	3	4
HNSC	SMC4 →	-0.662	-0.142	.002	.003	3	4
PDAC	TEAD4 →	-0.244	-0.134	.004	.006	3	4
COAD	TK1 →	-0.543	-0.155	.006	.002	3	4
COAD	SPAG5 →	-0.377	-0.106	.001	.006	3	4
LUAD	LILRB2 →	-0.489	-0.122	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019068 vs TRIM54 — LUAD

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