Receptor-mediated endocytosis of virus by host cell

Across TCGA patient cohorts, RNA activity of the Receptor-mediated endocytosis of virus by host cell pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPFIBP1, ACTN1, and DPP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated endocytosis of virus by host cell activity versus PPFIBP1 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPFIBP1 →	+0.399	+0.078	<.001	.004	3	8
GBM	ACTN1 →	+0.434	+0.096	<.001	<.001	3	8
OV	DPP4 →	+1.032	+0.065	<.001	<.001	3	7
BRCA	HTRA1 →	+0.712	+0.030	<.001	<.001	3	7
COAD	L3HYPDH →	+0.404	+0.039	.001	<.001	3	7
GBM	FLNA →	+0.498	+0.109	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019065 vs PPFIBP1 — LSCC

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