Receptor-mediated endocytosis of virus by host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated endocytosis of virus by host cell pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE2, LRRC26, and SEPTIN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated endocytosis of virus by host cell activity versus SERPINE2 in LUNG_NSCLC_LUAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SERPINE2 →	+3.152	+0.720	<.001	.001	3	5
BLOOD_Leukemia	LRRC26 →	-0.981	-1.038	.003	.005	3	5
LARGE_INTESTINE	SEPTIN3 →	-1.704	-1.043	.001	.004	3	5
BREAST	TJP3 →	-3.610	-1.774	<.001	<.001	3	5
BREAST	TPM4 →	+2.294	+1.174	.008	.003	3	5
LUNG_NSCLC_LUAD	PRSS23 →	+3.021	+1.073	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019065 vs SERPINE2 — LUNG_NSCLC_LUAD

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