Modulation by virus of host process

pathway activity — cross-omics
GO:0019048Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Modulation by virus of host process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTI2, MAK16, and EP300-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADTTI2 →+0.476+0.313<.001.00734
PDACMAK16 →+0.320+0.380.004.00433
OVEP300-AS1 →+0.565+0.167.009<.00133
PDACELF2 →+0.312+0.376<.001<.00133
PDACELP3 →+0.194+0.230<.001.00333
PDACRBM47 →+0.288+0.224.001.00533
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration