Protein palmitoylation

Across TCGA cell cohorts, RNA activity of the Protein palmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLUL, ABCC10, and PRRG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein palmitoylation activity versus GLUL in BLOOD_Leukemia (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GLUL →	+1.347	+1.184	<.001	<.001	3	4
BLOOD_Lymphoma	ABCC10 →	+0.927	+0.336	<.001	.004	3	4
LUNG_NSCLC_LUAD	PRRG2 →	+1.379	+1.265	.004	<.001	3	4
LUNG_NSCLC_LUAD	MKRN2OS →	+0.762	+0.947	.001	<.001	3	4
LUNG_NSCLC_LUAD	PRSS22 →	+2.259	+0.718	.003	.008	3	4
PANCREAS	FAM83E →	+2.862	+0.391	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018345 vs GLUL — BLOOD_Leukemia

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