Peptidyl-tyrosine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-tyrosine modification pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS4, NDUFB8, and TSSK6, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine modification activity versus DHRS4 in COAD (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DHRS4 →	-0.691	-0.997	.005	.007	3	1
COAD	NDUFB8 →	-0.756	-1.322	.005	.007	3	1
COAD	TSSK6 →	+0.476	+1.247	<.001	.005	3	1
COAD	MIR580 →	-1.380	-1.340	.006	<.001	3	1
COAD	THAP12P8 →	-0.076	-1.286	.006	.001	3	1
COAD	PPP1R8P1 →	-0.180	-1.419	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018212 vs DHRS4 — COAD

Explore this scatter interactively →