Peptidyl-threonine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-threonine modification pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LOX, MMP14, and RPL5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine modification activity versus LOX in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LOX →	+0.661	+0.046	<.001	<.001	3	6
COAD	MMP14 →	+0.399	+0.027	<.001	<.001	3	6
COAD	RPL5 →	-0.171	-0.028	<.001	<.001	3	5
COAD	SFRP2 →	+1.217	+0.031	<.001	<.001	3	5
OV	C1R →	+0.806	+0.058	<.001	<.001	3	5
OV	C1S →	+0.579	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018210 vs LOX — OV

Explore this scatter interactively →