Peptidyl-threonine modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-threonine modification pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HINFP, C11orf95, and AS3MT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine modification activity versus HINFP in BREAST (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HINFP →	+0.570	+0.557	.002	.001	3	5
BREAST	C11orf95 →	+0.874	+0.452	<.001	.001	3	4
BREAST	AS3MT →	+1.788	+0.422	<.001	.002	3	4
BONE	JKAMP →	-0.895	-0.300	<.001	<.001	3	4
KIDNEY	SAMD11 →	+2.343	+0.259	.001	.001	3	3
KIDNEY	TIGAR →	-1.546	-0.230	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018210 vs HINFP — BREAST

Explore this scatter interactively →