Peptidyl-arginine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-arginine modification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF728, LINC00702, and RNU6-786P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-arginine modification activity versus ZNF728 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF728 →	-0.911	-0.130	.009	.009	3	3
PDAC	LINC00702 →	-0.266	-0.067	.006	.005	3	3
PDAC	RNU6-786P →	-0.376	-0.105	.002	.001	3	3
HNSC	RNA5SP110 →	+0.396	+0.113	.002	<.001	3	3
HNSC	LINC01003 →	+0.313	+0.065	.008	.002	3	3
UCEC	GPT2 →	+0.690	+0.131	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018195 vs ZNF728 — OV

Explore this scatter interactively →