Protein oxidation

Across TCGA cell cohorts, RNA activity of the Protein oxidation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP11B, GTF3C4, and SLAMF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP11B grouped by Protein oxidation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATP11B →	-0.306	-1.656	.005	<.001	3	3
KIDNEY	GTF3C4 →	+0.258	+1.829	.006	.005	2	3
CNS	SLAMF1 →	-0.148	-1.726	<.001	<.001	3	2
CNS	BMP2 →	+0.283	+1.634	.001	<.001	3	2
CNS	TOP2A →	+0.293	+1.409	<.001	<.001	3	2
CNS	CYP1B1 →	+0.232	+1.688	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP11B by Protein oxidation activity — CNS

Explore this box plot interactively →