Peptide cross-linking

Across TCGA patient cohorts, RNA activity of the Peptide cross-linking pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CACYBP, ENTPD1, and SRSF9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide cross-linking activity versus CACYBP in LSCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CACYBP →	-0.433	-0.122	<.001	<.001	3	7
GBM	ENTPD1 →	+0.548	+0.224	<.001	<.001	3	7
GBM	SRSF9 →	-0.369	-0.126	<.001	.001	3	6
GBM	STX11 →	+0.611	+0.170	<.001	<.001	3	6
GBM	SVIL →	+0.552	+0.186	<.001	<.001	3	6
GBM	SYNE3 →	+0.237	+0.106	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018149 vs CACYBP — LSCC

Explore this scatter interactively →