Peptide cross-linking

Across TCGA pan-cancer cohorts, RNA activity of the Peptide cross-linking pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 28 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Peptide cross-linking pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and MESO, show the opposite pattern, with higher activity associated with better survival.

KIRP, LGG, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.147	0.611	.002	85	view →
LGG	DFS	Median	All	0.755	0.894	<.001	47	view →
ESCA	DFS	Quartile	III,IV	0.501	0.234	.010	36	view →
GBM	DFS	Quartile	All	0.145	0.346	.005	27	view →
MESO	DFS	Tertile	IV	0.578	0.174	.001	27	view →
OV	DFS	Median	II,III,IV	0.134	0.186	.022	26	view →
LIHC	OS	Median	II,III,IV	0.631	0.269	.004	24	view →
LAML	DFS	Tertile	All	0.270	0.514	.013	18	view →
KIRC	DFS	Quartile	All	0.544	0.658	.016	14	view →
KICH	OS	Quartile	II,III,IV	0.726	1.000	.024	10	view →
READ	DFS	Tertile	IV	0.562	0.985	.020	9	view →
TGCT	OS	Tertile	All	0.895	1.000	.027	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0018149–KIRP (DFS)

Open the KIRP breakdown →