Peptide cross-linking

Across TCGA patient cohorts, RNA activity of the Peptide cross-linking pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, PERP, and MPZL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide cross-linking activity versus DSP in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSP →	+1.292	+0.839	<.001	.001	3	7
BRCA	PERP →	+1.050	+0.255	<.001	<.001	3	6
HNSC	MPZL2 →	+1.143	+2.028	<.001	<.001	3	6
HNSC	DSC2 →	+1.255	+1.169	<.001	<.001	3	5
HNSC	ZNF185 →	+0.723	+1.088	.003	<.001	3	5
HNSC	ZBTB7B →	+0.864	+1.546	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018149 vs DSP — LSCC

Explore this scatter interactively →