Peptide cross-linking

Across TCGA cell cohorts, RNA activity of the Peptide cross-linking pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF692, IPO9, and LRRC31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF692 grouped by Peptide cross-linking-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF692 →	+0.253	+0.437	.003	.003	3	4
OVARY	IPO9 →	+0.255	+0.354	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	LRRC31 →	+0.310	+0.191	<.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	IL1R2 →	+0.180	+0.191	<.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	IRF5 →	+0.176	+0.191	.003	.002	3	3
UPPER_AERODIGESTIVE_TRACT	KDM1A →	-0.266	-0.268	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF692 by Peptide cross-linking activity — STOMACH

Explore this box plot interactively →