Peptide cross-linking

Across TCGA cell cohorts, RNA activity of the Peptide cross-linking pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, TGFB2, and CAV1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide cross-linking activity versus ANXA1 in LARGE_INTESTINE (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANXA1 →	+3.675	+0.421	<.001	<.001	3	6
PANCREAS	TGFB2 →	+2.056	+0.287	.002	.001	3	5
CNS	CAV1 →	+2.100	+0.335	.002	.001	2	6
LARGE_INTESTINE	CLIP4 →	+1.511	+0.306	.002	<.001	3	4
LARGE_INTESTINE	EMP1 →	+2.108	+0.265	<.001	<.001	3	4
PANCREAS	MDFI →	+3.125	+0.455	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018149 vs ANXA1 — LARGE_INTESTINE

Explore this scatter interactively →