Protein C-linked glycosylation

pathway activity — cross-omics
GO:0018103Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Protein C-linked glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPY19L1, ZNF773, and SCUBE3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCDPY19L1 →+1.064+0.181.001.00134
BRCAZNF773 →+0.440+0.651.002.00434
LUADSCUBE3 →+0.644+0.089.001<.00134
GBMEYS →-0.397-0.100.005.00433
GBMP2RX5 →-0.191-0.091.002.00724
CCRCCKRT8P31 →-0.498-0.878.004.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration