Peptidyl-lysine trimethylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine trimethylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP4, ERP44, and PRG4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine trimethylation activity versus FKBP4 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FKBP4 →	+0.392	+0.045	<.001	<.001	3	6
GBM	ERP44 →	-0.255	-0.043	<.001	<.001	3	6
UCEC	PRG4 →	-0.639	-0.052	<.001	<.001	3	6
BRCA	STUB1 →	+0.481	+0.041	<.001	<.001	3	5
OV	DCTPP1 →	+0.533	+0.036	.008	.009	3	5
GBM	TGM2 →	-0.548	-0.042	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018023 vs FKBP4 — LSCC

Explore this scatter interactively →