Regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, CCDC88B_S597, and FMNL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exocytosis activity versus SKAP2 in CCRCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SKAP2 →	+0.517	+0.031	<.001	<.001	3	8
LSCC	CCDC88B_S597 →	+0.972	+0.047	<.001	<.001	3	7
GBM	FMNL1 →	+0.557	+0.048	<.001	<.001	3	7
CCRCC	DEF6 →	+0.511	+0.030	<.001	<.001	3	7
UCEC	LSP1 →	+0.589	+0.037	<.001	<.001	3	7
CCRCC	APOBR →	+0.465	+0.028	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017157 vs SKAP2 — CCRCC

Explore this scatter interactively →