Calcium-ion regulated exocytosis

Across TCGA patient cohorts, RNA activity of the Calcium-ion regulated exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1C, KIF20B, and KIF20A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-ion regulated exocytosis activity versus TUBA1C in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TUBA1C →	-0.775	-0.952	.001	.002	3	6
LUAD	KIF20B →	-0.549	-0.787	.003	.008	3	5
UCEC	KIF20A →	-0.819	-0.802	.009	.005	3	5
BRCA	KIF2C →	-0.922	-0.519	<.001	.001	3	5
BRCA	MAMDC2 →	+0.831	+0.463	<.001	.004	3	5
LUAD	TAPT1 →	+0.659	+1.052	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017156 vs TUBA1C — GBM

Explore this scatter interactively →