Stem cell division

Across TCGA cell cohorts, RNA activity of the Stem cell division pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPRM1, SYNRG, and GPR148, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OPRM1 grouped by Stem cell division-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OPRM1 →	-0.134	-0.135	.008	.006	3	5
LUNG_NSCLC_LUAD	SYNRG →	+0.223	+0.121	.002	.001	3	5
STOMACH	GPR148 →	-0.235	-0.208	<.001	<.001	3	4
BREAST	RING1 →	-0.393	-0.118	.001	.006	3	4
BLOOD_Myeloma	SRPK1 →	-0.417	-0.135	<.001	.007	3	4
BREAST	ZSCAN32 →	+0.077	+0.112	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OPRM1 by Stem cell division activity — STOMACH

Explore this box plot interactively →