Protein import

Across TCGA cell cohorts, RNA activity of the Protein import pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFHD2, SLC10A5, and COL4A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import activity versus EFHD2 in LIVER (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EFHD2 →	-1.514	-0.305	<.001	<.001	2	5
LIVER	SLC10A5 →	+0.570	+0.306	.003	.005	3	4
OVARY	COL4A2 →	-2.724	-0.313	.009	.009	3	4
PANCREAS	NT5C →	-0.948	-0.476	.002	<.001	3	3
PANCREAS	KATNB1 →	+1.113	+0.410	.003	.004	3	3
PANCREAS	PELP1 →	+0.907	+0.541	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017038 vs EFHD2 — LIVER

Explore this scatter interactively →