Protein nitrosylation

Across TCGA patient cohorts, RNA activity of the Protein nitrosylation pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A8, S100A9, and S100A12, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein nitrosylation activity versus S100A8 in BLCA (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	S100A8 →	+3.695	+0.051	<.001	<.001	3	31
BRCA	S100A9 →	+3.040	+0.063	<.001	<.001	3	31
LAML	S100A12 →	+2.338	+0.057	<.001	<.001	3	29
LAML	LILRA5 →	+1.905	+0.072	<.001	<.001	3	24
BLCA	KLHDC7B-DT →	+1.080	+0.033	<.001	<.001	3	23
LAML	FCN1 →	+1.508	+0.048	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017014 vs S100A8 — BLCA

Explore this scatter interactively →