Protein nitrosylation

Across TCGA patient cohorts, RNA activity of the Protein nitrosylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A9, S100A12, and S100A8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein nitrosylation activity versus S100A9 in BRCA (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A9 →	+1.544	+0.082	<.001	<.001	3	8
BRCA	S100A12 →	+1.113	+0.059	<.001	<.001	3	7
BRCA	S100A8 →	+1.764	+0.083	<.001	<.001	3	6
BRCA	S100A9_T113 →	+1.331	+0.074	<.001	<.001	3	6
COAD	SART3 →	-0.164	-0.042	.003	.002	3	6
BRCA	CEBPB →	+0.609	+0.074	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017014 vs S100A9 — BRCA

Explore this scatter interactively →