Protein nitrosylation

Across TCGA cell cohorts, RNA activity of the Protein nitrosylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A18, TLE5, and CEP55, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A18 grouped by Protein nitrosylation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC22A18 →	-1.842	-0.873	.003	.008	3	4
LUNG_NSCLC_LUAD	TLE5 →	-1.197	-0.798	<.001	<.001	3	4
SKIN	CEP55 →	+0.828	+1.016	.004	.002	3	4
KIDNEY	CCDC40 →	-1.028	-0.236	.008	.001	3	4
BREAST	NECTIN3 →	+1.641	+0.760	.001	.003	3	4
BREAST	PDCD1LG2 →	+0.918	+0.640	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A18 by Protein nitrosylation activity — LIVER

Explore this box plot interactively →