Protein nitrosylation

Across TCGA cell cohorts, RNA activity of the Protein nitrosylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5PO, KDELR3, and NFYB, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein nitrosylation activity versus ATP5PO in BLOOD_Leukemia (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATP5PO →	+0.538	+0.495	.001	<.001	3	2
BREAST	KDELR3 →	-1.209	-0.270	<.001	.008	3	2
BREAST	NFYB →	+1.056	+0.380	.001	.001	3	2
BREAST	PHKG1 →	+1.545	+0.541	<.001	<.001	3	2
BREAST	S100A10 →	+1.927	+0.418	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	JTB →	-0.756	-0.238	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017014 vs ATP5PO — BLOOD_Leukemia

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