Protein sumoylation

Across TCGA cell cohorts, RNA activity of the Protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALNT3, TM7SF3, and CALD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B4GALNT3 grouped by Protein sumoylation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	B4GALNT3 →	+1.335	+0.173	.001	.001	3	5
LUNG_SCLC	TM7SF3 →	+1.171	+0.339	.001	.006	3	5
CNS	CALD1 →	-1.791	-0.201	<.001	<.001	3	5
OESOPHAGUS	MYADM →	-3.126	-0.440	.005	.005	3	4
LUNG_SCLC	ZNF692 →	+0.864	+0.372	.009	.006	3	4
BONE	RUNDC1 →	+0.764	+0.300	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B4GALNT3 by Protein sumoylation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →