Peroxisome fission

Across TCGA cell cohorts, RNA activity of the Peroxisome fission pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFYA, USP25, and UBE2R2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFYA grouped by Peroxisome fission-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NFYA →	-0.811	-0.232	.001	.008	3	5
URINARY_TRACT	USP25 →	+0.734	+0.376	.008	.008	3	4
PANCREAS	UBE2R2 →	-0.744	-0.195	<.001	.009	3	4
BREAST	STIMATE →	-0.672	-0.285	.006	.007	2	5
LUNG_NSCLC_LUAD	CSTF2 →	+0.625	+0.275	<.001	.002	3	3
LUNG_NSCLC_LUAD	ANKRD20A2P →	-0.367	-0.320	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFYA by Peroxisome fission activity — BREAST

Explore this box plot interactively →