Protein autoprocessing

Across TCGA cell cohorts, RNA activity of the Protein autoprocessing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM83B, PTDSS2, and CSTA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autoprocessing activity versus FAM83B in BREAST (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM83B →	-1.243	-0.188	.004	.003	3	4
BREAST	PTDSS2 →	+0.869	+0.257	<.001	.001	3	4
OESOPHAGUS	CSTA →	-4.289	-0.257	<.001	.002	3	4
PANCREAS	NEK6 →	+1.323	+0.219	.003	.001	3	4
CNS	SHPK →	+0.822	+0.275	.001	.003	3	4
BLOOD_Leukemia	HOXB3 →	+1.578	+0.143	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016540 vs FAM83B — BREAST

Explore this scatter interactively →