Protein processing

Across TCGA patient cohorts, RNA activity of the Protein processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COPZ2, FAP, and SNX9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein processing activity versus COPZ2 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COPZ2 →	+0.619	+0.020	<.001	<.001	3	9
OV	FAP →	+1.100	+0.036	<.001	<.001	3	9
OV	SNX9 →	+0.443	+0.033	<.001	<.001	3	8
BRCA	TLN2 →	+0.799	+0.032	<.001	<.001	3	8
CCRCC	ACTN1 →	+0.447	+0.021	.005	.003	3	8
BRCA	VCL →	+0.572	+0.036	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016485 vs COPZ2 — OV

Explore this scatter interactively →