Protein processing

Across TCGA patient cohorts, RNA activity of the Protein processing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1L2, SRPX, and TIMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein processing activity versus ALDH1L2 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ALDH1L2 →	+1.099	+0.270	.001	.002	3	5
BRCA	SRPX →	+1.189	+0.215	<.001	<.001	3	4
OV	TIMP1 →	+0.833	+0.166	.001	.001	3	4
OV	AEBP1 →	+1.737	+0.189	<.001	<.001	3	4
OV	ASPN →	+1.792	+0.177	<.001	<.001	3	4
OV	BCHE →	+1.208	+0.150	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016485 vs ALDH1L2 — BRCA

Explore this scatter interactively →