Protein processing

Across TCGA cell cohorts, RNA activity of the Protein processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIRBP, IRF1-AS1, and TMEM97, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIRBP grouped by Protein processing-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CIRBP →	-0.446	-0.149	.003	.001	3	5
BLOOD_Leukemia	IRF1-AS1 →	-1.583	-0.173	.004	.001	3	4
BLOOD_Myeloma	TMEM97 →	+1.218	+0.178	.005	.001	3	3
BLOOD_Myeloma	CDKN1A →	-3.202	-0.172	.002	.002	2	4
BLOOD_Myeloma	TRIM65 →	+1.195	+0.226	.005	<.001	3	3
LUNG_NSCLC_LUAD	ACBD5 →	+0.675	+0.134	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIRBP by Protein processing activity — BLOOD_Myeloma

Explore this box plot interactively →