Somatic diversification of immunoglobulins

Across TCGA cell cohorts, RNA activity of the Somatic diversification of immunoglobulins pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF852, PSMG3, and TMEM159, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF852 grouped by Somatic diversification of immunoglobulins-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF852 →	+0.726	+0.181	<.001	<.001	3	5
URINARY_TRACT	PSMG3 →	+0.699	+0.161	.007	.003	2	5
CNS	TMEM159 →	-1.010	-0.181	<.001	<.001	3	4
CNS	WEE1 →	+0.619	+0.211	<.001	.006	2	5
CNS	KLHL28 →	+0.459	+0.195	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	SAV1 →	+1.158	+0.180	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF852 by Somatic diversification of immunoglobulins activity — LARGE_INTESTINE

Explore this box plot interactively →