Somatic diversification of immunoglobulins

Across TCGA cell cohorts, RNA activity of the Somatic diversification of immunoglobulins pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC4, CENPM, and WDR76, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immunoglobulins activity versus RFC4 in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RFC4 →	+0.998	+0.294	.001	.004	3	8
STOMACH	CENPM →	+0.940	+0.468	.008	<.001	3	8
STOMACH	WDR76 →	+1.078	+0.368	.003	.001	3	7
UPPER_AERODIGESTIVE_TRACT	USP39 →	+0.685	+0.245	.006	.005	2	8
OESOPHAGUS	HSPD1 →	+0.875	+0.242	.002	.006	2	7
BREAST	MTFR2 →	+0.871	+0.299	.006	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016445 vs RFC4 — PANCREAS

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