Dendrite development

Across TCGA cell cohorts, RNA activity of the Dendrite development pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC31A, ZNF83, and FEN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC31A grouped by Dendrite development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SEC31A →	-0.240	-0.316	.002	.002	3	3
LUNG_NSCLC_LUSC	ZNF83 →	-0.226	-1.390	<.001	<.001	3	3
LUNG_NSCLC_LUSC	FEN1 →	-0.222	-1.390	.003	<.001	3	3
BREAST	CIRBP →	-0.274	-0.750	<.001	.001	3	3
OVARY	RXRG →	-0.149	-0.782	<.001	.002	3	3
LARGE_INTESTINE	FAT4 →	+0.130	+1.041	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC31A by Dendrite development activity — STOMACH

Explore this box plot interactively →