Dendrite development

Across TCGA pan-cancer cohorts, RNA activity of the Dendrite development pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 232 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Dendrite development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SCLC, show the opposite pattern, with higher activity associated with better survival.

UVM, KICH, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.254	0.805	<.001	99	view →
KICH	OS	Tertile	All	0.694	1.000	.002	82	view →
HNSC	DFS	Tertile	III,IV	0.707	0.501	<.001	77	view →
KIRP	OS	Tertile	All	0.458	0.761	<.001	39	view →
DLBC	DFS	Median	All	0.631	0.916	.012	33	view →
KIRC	DFS	Median	II,III,IV	0.366	0.647	<.001	30	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	18	view →
ESCA	OS	Tertile	III,IV	0.698	0.342	.007	17	view →
SKCM	OS	Quartile	II,III,IV	0.835	0.657	.002	16	view →
MESO	OS	Quartile	III,IV	0.306	0.510	.028	12	view →
READ	DFS	Median	IV	0.344	0.757	<.001	12	view →
CHOL	DFS	Quartile	All	0.081	0.565	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0016358–UVM (DFS)

Open the UVM breakdown →