Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA cell cohorts, RNA activity of the Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL16, WDR1, and WDR36, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules activity versus CXCL16 in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CXCL16 →	+0.990	+0.918	.006	.002	3	4
BLOOD_Lymphoma	WDR1 →	+0.902	+0.796	.001	.008	3	3
BLOOD_Myeloma	WDR36 →	-0.789	-0.989	<.001	.005	3	3
BLOOD_Myeloma	PHTF2 →	-0.884	-0.943	<.001	.008	3	3
LIVER	CNNM1 →	-1.985	-0.463	<.001	.001	3	3
LIVER	GPN1 →	+0.747	+0.408	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016339 vs CXCL16 — BLOOD_Lymphoma

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