Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

Across TCGA patient cohorts, RNA activity of the Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMC4, WDHD1, and CLDN23, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules activity versus SMC4 in KICH (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	SMC4 →	-1.545	-0.075	<.001	<.001	3	24
TGCT	WDHD1 →	-1.118	-0.104	<.001	<.001	3	23
ESCA	CLDN23 →	+2.284	+0.147	<.001	<.001	3	22
ESCA	CLDN3 →	+4.361	+0.156	<.001	<.001	3	21
KICH	CKAP2 →	-1.495	-0.070	<.001	.001	2	22
UCS	CLDN4 →	+2.858	+0.107	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016338 vs SMC4 — KICH

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