Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

pathway activity — cross-omics
GO:0016338Cross-omicsPROTEIN-MS → RNACellPairwise association · TCGA cohorts

Across TCGA cell cohorts, RNA activity of the Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNFN, ATP5F1B, and TOM1L1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules activity versus CNFN in LARGE_INTESTINE (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LARGE_INTESTINECNFN →-1.176-1.743.007.00132
LARGE_INTESTINEATP5F1B →-0.710-1.743.004.00132
LARGE_INTESTINETOM1L1 →-0.883-1.743.002.00132
LARGE_INTESTINETMEM161B →-0.676-1.743.002.00132
LARGE_INTESTINECSF2 →+1.146+1.743.004.00132
LARGE_INTESTINEBTNL9 →-3.153-1.743.005.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016338 vs CNFN — LARGE_INTESTINE

Per-sample scatter of Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules activity vs CNFN in LARGE_INTESTINE.

Explore this scatter interactively →

Exploration