Morphogenesis of embryonic epithelium

Across TCGA patient cohorts, RNA activity of the Morphogenesis of embryonic epithelium pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADNP, BTBD7, and NKTR, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of embryonic epithelium activity versus ADNP in LIHC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	ADNP →	+0.843	+0.027	<.001	<.001	3	32
THYM	BTBD7 →	+0.947	+0.057	<.001	<.001	3	32
UVM	NKTR →	+1.420	+0.026	<.001	<.001	3	32
THYM	PUM1 →	+0.897	+0.050	<.001	<.001	3	32
THYM	MGA →	+0.771	+0.044	<.001	<.001	3	32
UVM	TNRC6A →	+1.022	+0.020	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016331 vs ADNP — LIHC

Explore this scatter interactively →