Morphogenesis of embryonic epithelium

Across TCGA patient cohorts, RNA activity of the Morphogenesis of embryonic epithelium pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF5, WFS1, and ZPR1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of embryonic epithelium activity versus SRSF5 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRSF5 →	+0.859	+0.677	.001	.008	3	2
BRCA	WFS1 →	+1.220	+1.005	.006	.002	3	2
BRCA	ZPR1 →	-0.513	-0.759	.003	.005	3	2
BRCA	PLPPR4 →	+0.769	+0.718	.003	.009	3	2
BRCA	TGFB3 →	+1.893	+1.086	<.001	.001	3	2
BRCA	A1BG →	+0.234	+0.841	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016331 vs SRSF5 — BRCA

Explore this scatter interactively →