Morphogenesis of embryonic epithelium

Across TCGA cell cohorts, RNA activity of the Morphogenesis of embryonic epithelium pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIPAL3, TFAP4, and FRMD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIPAL3 grouped by Morphogenesis of embryonic epithelium-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NIPAL3 →	-1.231	-1.059	.002	.008	2	4
OESOPHAGUS	TFAP4 →	+0.876	+0.249	.004	.001	3	3
SKIN	FRMD6 →	-0.910	-0.836	.009	.004	3	3
SKIN	ZEB1 →	-1.192	-0.710	.004	.006	3	3
SKIN	KIRREL3 →	-0.964	-0.823	.002	.009	3	3
SKIN	SDCCAG8 →	-0.658	-0.771	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIPAL3 by Morphogenesis of embryonic epithelium activity — SOFT_TISSUE

Explore this box plot interactively →