Neuron remodeling

Across TCGA patient cohorts, RNA activity of the Neuron remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNMT, RPP40, and TNFAIP8L2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron remodeling activity versus RNMT in LSCC (Pearson r = -0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNMT →	-0.347	-0.052	<.001	<.001	3	6
BRCA	RPP40 →	-0.262	-0.044	<.001	<.001	3	6
OV	TNFAIP8L2 →	+0.624	+0.044	.004	.006	3	6
LSCC	WDR12 →	-0.387	-0.066	<.001	<.001	3	6
LSCC	WDR36 →	-0.276	-0.061	<.001	<.001	3	6
BRCA	WIPF1 →	+0.350	+0.045	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016322 vs RNMT — LSCC

Explore this scatter interactively →