O-glycan processing

Across TCGA cell cohorts, RNA activity of the O-glycan processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, MARCKSL1, and CATSPER1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR176 grouped by O-glycan processing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GPR176 →	-1.471	-0.654	.001	.009	3	4
BREAST	MARCKSL1 →	+0.948	+0.639	.004	<.001	3	4
OVARY	CATSPER1 →	-1.336	-0.703	.006	.008	3	4
BREAST	ALDH3B1 →	-1.485	-0.591	<.001	.001	3	4
CNS	NR1I3 →	+0.279	+0.683	.009	.001	3	4
OVARY	TMEM132A →	+0.984	+0.716	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR176 by O-glycan processing activity — BREAST

Explore this box plot interactively →