O-glycan processing

Across TCGA cell cohorts, RNA activity of the O-glycan processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT2, FNDC3B, and GORAB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, O-glycan processing activity versus GALNT2 in BLOOD_Lymphoma (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GALNT2 →	+2.626	+1.250	<.001	<.001	3	9
BLOOD_Lymphoma	FNDC3B →	+2.852	+1.488	<.001	<.001	3	7
STOMACH	GORAB →	+0.668	+1.032	.005	.002	3	5
BREAST	PIK3CD →	+1.570	+1.011	.002	.004	3	5
BLOOD_Lymphoma	LUZP1 →	+1.247	+1.283	.008	.001	3	5
BLOOD_Leukemia	ZFP36L1 →	+2.375	+0.852	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016266 vs GALNT2 — BLOOD_Lymphoma

Explore this scatter interactively →