Gap junction assembly

Across TCGA patient cohorts, RNA activity of the Gap junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3PXD2A_T256, RSU1, and TLN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gap junction assembly activity versus SH3PXD2A_T256 in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SH3PXD2A_T256 →	+0.711	+0.067	.008	<.001	3	9
BRCA	RSU1 →	+0.386	+0.045	<.001	<.001	3	8
LSCC	TLN1 →	+0.338	+0.076	<.001	<.001	3	8
OV	CAVIN3 →	+0.520	+0.065	.002	<.001	3	8
GBM	COL3A1 →	+0.635	+0.081	.004	.001	3	8
COAD	CSRP1 →	+0.585	+0.027	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016264 vs SH3PXD2A_T256 — OV

Explore this scatter interactively →