Gap junction assembly

Across TCGA patient cohorts, RNA activity of the Gap junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DACT3, TAL1, and MSRB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gap junction assembly activity versus DACT3 in UCEC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DACT3 →	+1.132	+0.466	<.001	.003	3	7
GBM	TAL1 →	+0.542	+0.270	<.001	<.001	3	6
COAD	MSRB3 →	+0.906	+0.732	.001	.003	3	6
BRCA	LINC00702 →	+0.502	+1.028	<.001	<.001	3	6
GBM	IRAG1 →	+0.628	+0.360	<.001	<.001	3	6
COAD	JAM2 →	+0.573	+0.658	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016264 vs DACT3 — UCEC

Explore this scatter interactively →