Attachment of GPI anchor to protein

Across TCGA patient cohorts, RNA activity of the Attachment of GPI anchor to protein pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAT2, WDR35, and ADNP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of GPI anchor to protein activity versus BCAT2 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCAT2 →	+0.360	+0.046	<.001	.001	3	5
LSCC	WDR35 →	+0.329	+0.055	<.001	.002	3	5
LSCC	ADNP →	+0.324	+0.066	.003	<.001	3	5
LSCC	LARP1 →	-0.171	-0.055	.001	<.001	3	5
PDAC	OSBPL3 →	-0.256	-0.065	.002	<.001	3	5
LSCC	RALGAPB →	+0.254	+0.066	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016255 vs BCAT2 — GBM

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