Negative regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Negative regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3B, POMT2, and SUPT3H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB3B grouped by Negative regulation of macroautophagy-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RAB3B →	-2.120	-0.249	.002	<.001	3	4
OVARY	POMT2 →	+0.655	+0.325	<.001	.004	3	4
BLOOD_Myeloma	SUPT3H →	-1.228	-0.283	.007	<.001	3	4
LIVER	BAMBI →	+2.198	+0.318	<.001	<.001	3	4
BLOOD_Lymphoma	IMP4 →	+1.560	+0.483	<.001	.009	3	4
BLOOD_Lymphoma	ADCY1 →	-1.090	-0.439	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB3B by Negative regulation of macroautophagy activity — LUNG_SCLC

Explore this box plot interactively →