Positive regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB1, TRAP1, and TUFM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCARB1 grouped by Positive regulation of macroautophagy-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SCARB1 →	+1.008	+0.138	.004	.002	3	4
OVARY	TRAP1 →	+0.850	+0.202	.001	.001	3	4
OESOPHAGUS	TUFM →	+0.756	+0.283	.005	<.001	3	4
LUNG_SCLC	IFIT3 →	-1.329	-0.138	.005	.004	3	4
CNS	LOXL2 →	-1.905	-0.323	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	FSTL1 →	-2.307	-0.165	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCARB1 by Positive regulation of macroautophagy activity — PANCREAS

Explore this box plot interactively →