Positive regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP1, PARD6G, and CACNA1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macroautophagy activity versus VAMP1 in LUNG_NSCLC_LUAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	VAMP1 →	-0.880	-0.160	<.001	<.001	3	5
CNS	PARD6G →	-1.192	-0.242	<.001	<.001	3	4
LUNG_SCLC	CACNA1B →	-1.785	-0.167	.003	.007	3	4
OESOPHAGUS	LIMK2 →	+1.236	+0.146	.006	.007	3	4
BONE	TUBB4A →	-3.542	-0.214	.005	.007	3	4
BONE	TRMT10A →	+0.742	+0.199	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016239 vs VAMP1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →